Anderson, M. A. et al. Natural and targeted circuit reorganization after spinal cord injury. Nat. Neurosci. 25, 1584–1596 (2022).
Courtine, G. & Sofroniew, M. V. Spinal cord repair: advances in biology and technology. Nat. Med. 25, 898–908 (2019).
Google Scholar
Wilson, J., Hashimoto, R., Dettori, J. & Fehlings, M. Spinal cord injury and quality of life: a systematic review of outcome measures. Evid. Based Spine Care 2, 37–44 (2011).
Google Scholar
Kokotilo, K. J., Eng, J. J. & Curt, A. Reorganization and preservation of motor control of the brain in spinal cord injury: a systematic review. J. Neurotrauma 26, 2113–2126 (2009).
Google Scholar
Gomes-Osman, J., Cortes, M., Guest, J. & Pascual-Leone, A. A systematic review of experimental strategies aimed at improving motor function after acute and chronic. J. Neurotrauma 33, 425–438 (2016).
Google Scholar
Munce, S. E. P. et al. Impact of quality improvement strategies on the quality of life and well-being of individuals with spinal cord injury: a systematic review protocol. Syst. Rev. 2, 14 (2013).
Google Scholar
Asboth, L. et al. Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion. Nat. Neurosci. 21, 576–588 (2018).
Google Scholar
Kathe, C. et al. The neurons that restore walking after paralysis. Nature 611, 540–547 (2022).
Wenger, N. et al. Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury. Nat. Med. 22, 138–145 (2016).
Google Scholar
van den Brand, R. et al. Restoring voluntary control of locomotion after paralyzing spinal cord injury. Science 336, 1182–1185 (2012).
Google Scholar
Capogrosso, M. et al. A brain–spine interface alleviating gait deficits after spinal cord injury in primates. Nature 539, 284–288 (2016).
Google Scholar
Squair, J. W. et al. Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury. Nature 590, 308–314 (2021).
Google Scholar
Lavrov, I. et al. Epidural stimulation induced modulation of spinal locomotor networks in adult spinal rats. J. Neurosci. 28, 6022–6029 (2008).
Google Scholar
Squair, J. W. et al. Implanted system for orthostatic hypotension in multiple-system atrophy. N. Engl. J. Med. 386, 1339–1344 (2022).
Google Scholar
Alam, M. et al. Electrical neuromodulation of the cervical spinal cord facilitates forelimb skilled function recovery in spinal cord injured rats. Exp. Neurol. 291, 141–150 (2017).
Google Scholar
Shah, P. et al. Unique spatiotemporal neuromodulation of the lumbosacral circuitry shapes locomotor success after spinal cord injury. J. Neurotrauma 33, 1709–1723 (2016).
Google Scholar
Barra, B. et al. Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys. Nat. Neurosci. 25, 924–934 (2022).
Harkema, S. et al. Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study. Lancet 377, 1938–1947 (2011).
Google Scholar
Harkema, S. J. et al. Epidural spinal cord stimulation training and sustained recovery of cardiovascular function in individuals with chronic cervical spinal cord injury. JAMA Neurol. 75, 1569–1571 (2018).
Google Scholar
Angeli, C. A. et al. Recovery of over-ground walking after chronic motor complete spinal cord injury. N. Engl. J. Med. 379, 1244–1250 (2018).
Google Scholar
Gill, M. L. et al. Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia. Nat. Med. 24, 1677–1682 (2018).
Google Scholar
Darrow, D. et al. Epidural spinal cord stimulation facilitates immediate restoration of dormant motor and autonomic supraspinal pathways after chronic neurologically complete spinal cord injury. J. Neurotrauma 36, 2325–2336 (2019).
Google Scholar
Rowald, A. et al. Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis. Nat. Med. 28, 260–271 (2022).
Google Scholar
Wagner, F. B. et al. Targeted neurotechnology restores walking in humans with spinal cord injury. Nature 563, 65–71 (2018).
Google Scholar
Hofstoetter, U. S. et al. Modification of spasticity by transcutaneous spinal cord stimulation in individuals with incomplete spinal cord injury. J. Spinal Cord Med. 37, 202–211 (2014).
Google Scholar
Hofstoetter, U. S. et al. Transcutaneous spinal cord stimulation induces temporary attenuation of spasticity in individuals with spinal cord injury. J. Neurotrauma 37, 481–493 (2020).
Google Scholar
Phillips, A. A. et al. An autonomic neuroprosthesis: noninvasive electrical spinal cord stimulation restores autonomic cardiovascular function in individuals with spinal cord injury. J. Neurotrauma 35, 446–451 (2018).
Google Scholar
Kreydin, E. et al. Transcutaneous electrical spinal cord neuromodulator (TESCoN) improves symptoms of overactive bladder. Front. Syst. Neurosci. 14, 1 (2020).
Google Scholar
Gad, P. N., Kreydin, E., Zhong, H., Latack, K. & Edgerton, V. R. Non-invasive neuromodulation of spinal cord restores lower urinary tract function after paralysis. Front. Neurosci. 12, 432 (2018).
Google Scholar
Herrity, A. N., Williams, C. S., Angeli, C. A., Harkema, S. J. & Hubscher, C. H. Lumbosacral spinal cord epidural stimulation improves voiding function after human spinal cord injury. Sci. Rep. 8, 8688 (2018).
Google Scholar
Lu, D. C. et al. Engaging cervical spinal cord networks to reenable volitional control of hand function in tetraplegic patients. Neurorehabil. Neural Repair 30, 951–962 (2016).
Google Scholar
Gad, P. et al. Non-invasive activation of cervical spinal networks after severe paralysis. J. Neurotrauma 35, 2145–2158 (2018).
Google Scholar
Inanici, F., Brighton, L. N., Samejima, S., Hofstetter, C. P. & Moritz, C. T. Transcutaneous spinal cord stimulation restores hand and arm function after spinal cord injury. IEEE Trans. Neural Syst. Rehabil. Eng. 29, 310–319 (2021).
Inanici, F. et al. Transcutaneous electrical spinal stimulation promotes long-term recovery of upper extremity function in chronic tetraplegia. IEEE Trans. Neural Syst. Rehabil. Eng. 26, 1272–1278 (2018).
Google Scholar
Sharma, P. et al. Multi-site spinal cord transcutaneous stimulation facilitates upper limb sensory and motor recovery in severe cervical spinal cord injury: a case study. J. Clin. Med. 12, 4416 (2023).
Google Scholar
Benavides, F. D. et al. Cortical and subcortical effects of transcutaneous spinal cord stimulation in humans with tetraplegia. J. Neurosci. 40, 2633–2643 (2020).
Google Scholar
Rejc, E., Angeli, C. A., Atkinson, D. & Harkema, S. J. Motor recovery after activity-based training with spinal cord epidural stimulation in a chronic motor complete paraplegic. Sci. Rep. 7, 13476 (2017).
Google Scholar
Powell, M. P. et al. Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis. Nat. Med. 29, 689–699 (2023).
Hoffman, L. R. & Field-Fote, E. C. Functional and corticomotor changes in individuals with tetraplegia following unimanual or bimanual massed practice training with somatosensory stimulation: a pilot study. J. Neurol. Phys. Ther. 34, 193–201 (2010).
Google Scholar
Kumru, H. et al. Transcutaneous electrical neuromodulation of the cervical spinal cord depends both on the stimulation intensity and the degree of voluntary activity for training. a pilot study. J. Clin. Med. 10, 3278 (2021).
Google Scholar
Jo, H. J. & Perez, M. A. Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury. Brain 143, 1368–1382 (2020).
Google Scholar
Courtine, G., Harkema, S. J., Dy, C. J., Gerasimenko, Y. P. & Dyhre-Poulsen, P. Modulation of multisegmental monosynaptic responses in a variety of leg muscles during walking and running in humans. J. Physiol. 582, 1125–1139 (2007).
Google Scholar
National Spinal Cord Injury Statistical Center. Traumatic Spinal Cord Injury Facts and Figures at a Glance. https://msktc.org/sites/default/files/SCI-Facts-Figs-2022-Eng-508.pdf (2022).
Gomes-Osman, J., Tibbett, J. A., Poe, B. P. & Field-Fote, E. C. Priming for improved hand strength in persons with chronic tetraplegia: a comparison of priming-augmented functional task practice, priming alone, and conventional exercise training. Front. Neurol. 7, 242 (2017).
Google Scholar
Hoffman, L. & Field-Fote, E. Effects of practice combined with somatosensory or motor stimulation on hand function in persons with spinal cord injury. Top. Spinal Cord. Inj. Rehabil. 19, 288–299 (2013).
Google Scholar
Beekhuizen, K. S. & Field-Fote, E. C. Sensory stimulation augments the effects of massed practice training in persons with tetraplegia. Arch. Phys. Med. Rehabil. 89, 602–608 (2008).
Google Scholar
Diong, J. et al. Incidence and predictors of contracture after spinal cord injury—a prospective cohort study. Spinal Cord 50, 579–584 (2012).
Google Scholar
Garcia-Arguello, L. Y. et al. Infections in the spinal cord-injured population: a systematic review. Spinal Cord 55, 526–534 (2017).
Google Scholar
Waters, R. L., Adkins, R. H., Yakura, J. S. & Sie, I. Motor and sensory recovery following incomplete tetraplegia. Arch. Phys. Med. Rehabil. 75, 306–311 (1994).
Google Scholar
Mateo, S., Marco, J. D., Cucherat, M., Gueyffier, F. & Rode, G. Inconclusive efficacy of intervention on upper-limb function after tetraplegia: a systematic review and meta-analysis. Ann. Phys. Rehabil. Med. 63, 230–240 (2020).
Google Scholar
Kalsi-Ryan, S. et al. Outcome of the upper limb in cervical spinal cord injury: profiles of recovery and insights for clinical studies. J. Spinal Cord Med. 37, 503–510 (2014).
Google Scholar
Strollo, P. J. et al. Upper-airway stimulation for obstructive sleep apnea. N. Engl. J. Med. 370, 139–149 (2014).
Google Scholar
Anand, A. et al. Ketamine versus ECT for nonpsychotic treatment-resistant major depression. N. Engl. J. Med. 388, 2315–2325 (2023).
Google Scholar
Pluymaekers, N. A. H. A. et al. Early or delayed cardioversion in recent-onset atrial fibrillation. N. Engl. J. Med. 380, 1499–1508 (2019).
Google Scholar
Blumberger, D. M. et al. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial. Lancet 391, 1683–1692 (2018).
Google Scholar
Amundsen, C. L. et al. OnabotulinumtoxinA vs sacral neuromodulation on refractory urgency urinary incontinence in women: a randomized clinical trial. JAMA 316, 1366–1374 (2016).
Google Scholar
Martínez-Fernández, R. et al. Randomized trial of focused ultrasound subthalamotomy for Parkinson’s disease. N. Engl. J. Med. 383, 2501–2513 (2020).
Google Scholar
Kupsch, A. et al. Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N. Engl. J. Med. 355, 1978–1990 (2006).
Google Scholar
Mallet, L. et al. Subthalamic nucleus stimulation in severe obsessive–compulsive disorder. N. Engl. J. Med. 359, 2121–2134 (2008).
Google Scholar
Rowald, A. et al. Recovery of trunk and leg motor functions within one day after chronic complete paralysis. Nat. Med. (in the press).
Lammertse, D. et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. Spinal Cord 45, 232–242 (2007).
Google Scholar
Milekovic, T. et al. A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease. Nat. Med. 29, 2854–2865 (2023).
Kirshblum, S. & Waring, W. Updates for the International Standards for Neurological Classification of Spinal Cord Injury. Phys. Med. Rehabil. Clin. North Am. 25, 505–517 (2014).
Google Scholar
Kalsi-Ryan, S. et al. The graded redefined assessment of strength sensibility and prehension: reliability and validity. J. Neurotrauma 29, 905–914 (2012).
Google Scholar
Gerasimenko, Y. et al. Transcutaneous electrical spinal-cord stimulation in humans. Ann. Phys. Rehabil. Med. 58, 225–231 (2015).
Google Scholar
Selya, A. S., Rose, J. S., Dierker, L. C., Hedeker, D. & Mermelstein, R. J. A practical guide to calculating Cohen’s f2, a measure of local effect size, from PROC MIXED. Front. Psychol. 3, 111 (2012).
Google Scholar
Kirshblum, S. C. et al. Reference for the 2011 revision of the International Standards for Neurological Classification of Spinal Cord Injury. J. Spinal Cord Med. 34, 547–554 (2011).
Google Scholar
Marino, R. J., Kern, S. B., Leiby, B., Schmidt-Read, M. & Mulcahey, M. J. Reliability and validity of the capabilities of upper extremity test (CUE-T) in subjects with chronic spinal cord injury. J. Spinal Cord Med. 38, 498–504 (2015).
Google Scholar
Herdman, M. et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual. Life Res. 20, 1727–36 (2011).
Google Scholar
Catz, A., Itzkovich, M., Agranov, E., Ring, H. & Tamir, A. SCIM—spinal cord independence measure: a new disability scale for patients with spinal cord lesions. Spinal Cord 35, 850–856 (1997).
Google Scholar
Jang, Y., Hsieh, C.-L., Wang, Y.-H. & Wu, Y.-H. A validity study of the WHOQOL-BREF assessment in persons with traumatic spinal cord injury. Arch. Phys. Med. Rehabil. 85, 1890–1895 (2004).
Google Scholar
Widerström-Noga, E. et al. The international spinal cord injury pain basic data set. Spinal Cord 46, 818–823 (2008).
Google Scholar
Measuring Functioning and Well-Being: The Medical Outcomes Study Approach (eds Stewart, A. & Ware, J.) (RAND, 1992); https://doi.org/10.7249/CB361
Mills, P. B., Vakil, A. P., Phillips, C., Kei, L. & Kwon, B. K. Intra-rater and inter-rater reliability of the Penn Spasm Frequency Scale in people with chronic traumatic spinal cord injury. Spinal Cord 56, 569–574 (2018).
Google Scholar
Contributors et al. International standards to document remaining autonomic function after spinal cord injury. J. Spinal Cord Med. 35, 201–210 (2012).
Google Scholar
Kroenke, K., Spitzer, R. L. & Williams, J. B. W. The PHQ-9: validity of a brief depression severity measure. J. Gen. Intern. Med. 16, 606–613 (2001).
Google Scholar
Kamper, S. J., Maher, C. G. & Mackay, G. Global rating of change scales: a review of strengths and weaknesses and considerations for design. J. Man. Manip. Ther. 17, 163–170 (2009).
Google Scholar
Squair, J. W. et al. Empirical targets for acute hemodynamic management of individuals with spinal cord injury. Neurology 93, e1205–e1211 (2019).
Google Scholar
Squair, J. W. et al. Spinal cord perfusion pressure predicts neurologic recovery in acute spinal cord injury. Neurology 89, 1660–1667 (2017).
Google Scholar
Πηγή άρθρου : www.nature.com